What is TIVA (and why choose it)?
- TIVA = maintaining general anaesthesia using intravenous drugs (commonly propofol + an opioid such as remifentanil), rather than inhaled volatile agents.
- Often delivered using a target-controlled infusion (TCI): a pump that aims for a chosen drug concentration (e.g., effect-site target for propofol).
- Main reasons to choose TIVA: reduce postoperative nausea/vomiting (PONV), avoid volatile-related issues, improve conditions for certain surgeries, and provide stable anaesthesia when gases are impractical.
High PONV risk (common and exam-relevant)
- TIVA with propofol reduces PONV compared with volatile anaesthesia (useful in patients with previous severe PONV or multiple risk factors).
- Particularly helpful for day-case surgery where early discharge matters.
- Still use multimodal antiemetics as indicated (TIVA reduces risk but does not eliminate it).
Airway surgery and shared-airway cases
- Useful when the surgeon needs access to the airway (e.g., microlaryngoscopy, bronchoscopy) and volatile delivery may be unreliable due to leaks or open circuits.
- Maintains anaesthesia when ventilation is intermittent or via non-standard techniques (e.g., jet ventilation) where end-tidal agent monitoring is limited.
- Plan depth monitoring carefully (clinical signs ± processed EEG if used locally) because you may not have end-tidal agent as a guide.
Neurosurgery and neuro-anaesthesia considerations
- Propofol-based TIVA can help provide a “slack brain” (reduced cerebral blood flow and intracranial pressure) compared with some volatile techniques.
- Useful when stable physiology and rapid wake-up for neurological assessment are desired.
- Common in cases needing neurophysiological monitoring (e.g., motor evoked potentials), where volatile agents can suppress signals (local protocols vary).
When inhalational anaesthesia is undesirable or impractical
- Malignant hyperthermia (MH) susceptibility: avoid triggering agents (volatile agents and suxamethonium); TIVA is a standard approach (ensure full MH precautions and machine preparation).
- Severe bronchospasm/reactive airways: propofol and opioids may be better tolerated than pungent volatiles in some patients (individualise; ensure bronchodilator plan).
- Poor access to anaesthetic machine or scavenging limitations (e.g., some remote locations): TIVA may be logistically simpler, but only if infusion equipment and monitoring are robust.
Procedures needing stillness or controlled conditions
- Some ENT, ophthalmic, and interventional radiology procedures benefit from minimal movement and stable depth (remifentanil is useful for intense, short-lived stimulation).
- Useful when you want predictable wake-up (e.g., short cases, rapid turnover), especially with remifentanil and careful propofol titration.
- Can be advantageous where low fresh gas flows/volatile wash-in and wash-out would otherwise slow control of depth.
Practical tips for new starters (safe first-time use)
- Always run a continuous opioid alongside propofol for surgical anaesthesia (propofol alone is not enough for most operations).
- Use a dedicated IV cannula for infusions where possible; check patency before induction and re-check after positioning/draping.
- Secure lines well and keep the cannula visible if feasible; extravasation or disconnection can cause awareness.
- Have a clear plan for: induction, maintenance targets, analgesia, antiemetics, and emergence (including postoperative pain plan if using remifentanil).
- If using neuromuscular blockade, ensure appropriate monitoring and reversal plan; paralysis can mask inadequate depth.
- Document drug concentrations, pump settings/targets, and any changes with time stamps.
What does TIVA stand for and what is the usual drug combination?
Total intravenous anaesthesia. Commonly propofol (hypnotic) + an opioid infusion (often remifentanil; sometimes alfentanil/fentanyl) ± muscle relaxant as needed.
When is TIVA particularly useful for day-case patients?
– High PONV risk – Previous severe PONV – When early eating/drinking and discharge are priorities
Why can TIVA be useful in shared-airway surgery?
– Volatile delivery may be unreliable due to leaks/open airway – End-tidal agent monitoring may be limited – IV delivery maintains anaesthesia independent of the airway circuit
When should you strongly consider TIVA for MH risk?
Known or suspected MH susceptibility: avoid volatile agents and suxamethonium; use a non-trigger technique (often propofol-based TIVA) with full MH precautions and prepared equipment.
What is the main safety concern with TIVA compared with volatile anaesthesia?
– Accidental interruption of drug delivery (disconnection, occlusion, empty syringe, wrong line) – Risk of awareness if infusion stops, especially if paralysed
How do you reduce the risk of awareness with TIVA?
– Check IV access and secure lines – Use reliable pumps and correct drug concentrations – Regularly confirm infusion running and syringe volume – Consider depth monitoring where appropriate and follow local policy – Avoid long periods of paralysis without reassurance of adequate anaesthesia
Why can remifentanil be a double-edged sword?
– Great for intense, short stimulation and rapid wake-up – But it wears off quickly: you must plan longer-acting analgesia (e.g., morphine/oxycodone, regional block, paracetamol/NSAID if appropriate) before stopping it
Is propofol alone enough for surgical anaesthesia?
Usually no. Propofol provides hypnosis (sleep) but limited analgesia; most surgery needs an opioid and/or regional/local anaesthesia.
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