Definition (core concept)
- TIVA = Total Intravenous Anaesthesia: general anaesthesia delivered using IV drugs (for hypnosis ± analgesia), without using volatile (inhaled) anaesthetic agents.
- Usually delivered using an infusion pump (often a target-controlled infusion, TCI) rather than repeated boluses.
- Common drug combination: propofol (for unconsciousness) + an opioid such as remifentanil (for analgesia and blunting responses).
- You may still use oxygen/air via a breathing circuit and ventilator; “TIVA” refers to the anaesthetic drugs, not the gases.
Why use TIVA? (common indications)
- High risk of postoperative nausea and vomiting (PONV) or previous severe PONV: TIVA (propofol-based) reduces PONV compared with volatiles.
- Airway surgery or shared airway (e.g., ENT): avoids volatile contamination and can be smoother in some setups.
- Malignant hyperthermia susceptibility: avoid triggering agents (volatile agents and suxamethonium); TIVA is part of a trigger-free technique.
- When stable depth control is desired (e.g., some neurosurgery cases) or where volatile delivery is impractical.
What you need to run TIVA safely (minimum essentials)
- A reliable IV cannula (ideally a large-bore cannula in a good vein) and a plan for what to do if IV access fails.
- A dedicated infusion pump for propofol (and a second pump for opioid if used). If using TCI, confirm correct model and patient details (age, weight, height).
- Standard monitoring: ECG, non-invasive BP, pulse oximetry, capnography, temperature; consider depth of anaesthesia monitoring (e.g., processed EEG) where appropriate/available.
- A clear labelling system: label syringes and lines; keep propofol and opioid lines separate and traceable to the patient.
- A plan for airway management and ventilation as per any general anaesthetic (TIVA does not remove the need for airway vigilance).
How TIVA is typically delivered (new-starter overview)
- Induction: often a propofol bolus (plus opioid) to induce unconsciousness, then start/continue propofol infusion (and opioid infusion if used).
- Maintenance: propofol infusion provides hypnosis; opioid infusion provides analgesia and helps control responses to surgery.
- Emergence: stop/step down infusions in time for wake-up; anticipate that remifentanil wears off very quickly, so ensure a plan for postoperative analgesia.
- Always match drug delivery to clinical signs and monitoring; avoid “set and forget” infusions.
First-time practical tips (things that prevent problems)
- Before starting: check pump settings, syringe size, drug concentration, and that the line is connected to the patient (not to a dead-end or another line).
- Use anti-siphon/anti-reflux valves if required by local policy; be aware of the risk of free-flow if a syringe is not correctly seated in the pump.
- Secure the IV and extension set; keep the cannula visible if possible so you can spot tissuing/extravasation early.
- If using remifentanil: plan postoperative pain relief early (e.g., longer-acting opioid, regional block, paracetamol/NSAID if appropriate).
- Consider PONV prophylaxis even with TIVA if the patient is high risk (multimodal approach).
Common “first shift” scenarios
- High PONV risk day-case: propofol-based TIVA + multimodal antiemetics; ensure timely wake-up and good analgesia plan.
- ENT/shared airway: confirm with surgeon how airway will be managed; ensure pumps and lines are positioned safely and not obstructing access.
- Suspected IV problem mid-case: sudden tachycardia/hypertension/movement with rising BIS (if used) may suggest inadequate anaesthesia—check IV patency and infusion delivery immediately.
- Transfer to recovery: clearly hand over what infusions were used, when stopped, and what analgesia has been given/needs giving.
What does TIVA stand for?
Total Intravenous Anaesthesia: GA maintained using IV anaesthetic drugs rather than inhaled volatile agents.
What are the usual drugs in a basic TIVA technique?
– Propofol infusion for hypnosis – Opioid (often remifentanil) for analgesia and to blunt responses – Muscle relaxant if needed for intubation/surgery (not mandatory for all cases)
Do patients still receive oxygen and ventilation during TIVA?
Yes. You still deliver oxygen/air and manage the airway/ventilation as with any general anaesthetic; TIVA just changes how the anaesthetic is delivered.
What is TCI?
Target-Controlled Infusion: a pump uses a pharmacokinetic model to target a chosen drug concentration (e.g., effect-site or plasma), adjusting the infusion rate automatically.
Why does TIVA reduce PONV?
Propofol is less likely to cause nausea/vomiting than volatile agents; avoiding volatiles can reduce PONV risk.
What is the biggest safety risk unique to TIVA?
Accidental under-delivery of anaesthetic (e.g., disconnected/blocked IV, pump error) leading to awareness. Vigilant checks of IV patency, pump function, and clinical signs are essential.
How do I know the patient is deep enough under TIVA?
– Clinical signs: movement, sweating, tearing, tachycardia, hypertension – End-tidal CO2 and ventilator synchrony – Consider processed EEG depth monitoring where appropriate – Always check drug delivery/IV patency if signs suggest light anaesthesia
Why can pain be a problem after remifentanil TIVA?
Remifentanil wears off within minutes. If you don’t give longer-acting analgesia (or use regional techniques), the patient can wake in significant pain.
Is TIVA the same as sedation?
No. TIVA usually refers to general anaesthesia (unconsciousness) maintained with IV drugs; sedation is a lighter state and may not require airway instrumentation.
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